Hematologic Malignancies: Unraveling Blood Cancers

1. Leukemia:

Description: Leukemia begins in the bone marrow, where abnormal cells (usually white blood cells) multiply uncontrollably.

Types:

Acute Lymphoblastic Leukemia (ALL): Common in children and adolescents.

Acute Myeloid Leukemia (AML): Affects myeloid cells.

Chronic Lymphocytic Leukemia (CLL): Slow-growing and common in older adults.

Chronic Myelogenous Leukemia (CML): Associated with the Philadelphia chromosome

2. Lymphoma:

Description: Lymphoma originates in the lymphatic system (including lymph nodes, spleen, and bone marrow).

Types:

Hodgkin Lymphoma: Characterized by Reed-Sternberg cells.

Non-Hodgkin Lymphoma (NHL): Diverse subtypes, including B-cell and T-cell lymphomas.

Waldenstrom Macroglobulinemia: Rare lymphoplasmacytic lymphoma.

Follicular Lymphoma: Slow-growing B-cell lymphoma.

Cutaneous T-Cell Lymphoma: Affects skin.

3. Multiple Myeloma:

Description: Myeloma arises from plasma cells in the bone marrow.

Features: Abnormal plasma cells produce excess monoclonal proteins (M-proteins).

Hematological Malignancies- A comprehensive menu of tests offered to understand the genetic basis of leukemias for Diagnostics, Therapeutics, and Prognostics. NGS, DDPCR, Real-Time PCR, and Cytogenomics assays are offered to better understand the Hematological Malignancies.