Introduction to Whole Exome Sequencing
Whole exome sequencing (WES) is an advanced technique that focuses on sequencing all the protein-coding regions of genes in a genome. This comprehensive approach ensures that the most relevant genetic information is captured efficiently.
Importance of Mitochondrial DNA Analysis
Mitochondrial DNA (mtDNA) analysis plays a crucial role in genetic research. Unlike nuclear DNA, mtDNA is inherited maternally and can provide unique insights into genetic disorders, evolutionary biology, and ancestral heritage.
Advantages of Combining WES and mtDNA Analysis
Combining whole exome sequencing with mitochondrial DNA analysis offers a holistic view of the genome. This integrated approach increases diagnostic accuracy, enabling the identification of both nuclear and mitochondrial mutations, which can enhance our understanding of complex genetic conditions.